Metoprolol 47 5mg retard

The treatment of essential hypertension. Comparison of efficacy and tolerance of combined therapy with metoprolol Seloken plus spironolactone Aldactone and metoprolol plus bendroflumethiazide with potassium chloride. Clinical Trials Journal A dose regimen for metoprolol in the treatment of myocardial infarction. Journal of Pharmacy and Pharmacology 34 Dec.

The acute electrophysiological effects of intravenous metoprolol. Antiplatelet activity of beta-adrenergic antagonists: Influence of cardioselectivity and respiratory disease on pulmonary responsiveness to beta-blockade. Genetically determined variability in acetylation and oxidation. Plasma levels and effects of metoprolol after single and multiple oral doses. Clinical Pharmacology and Therapeutics Long-term treatment of hypertension.

Effects of chlorthalidone Igioton and metoprolol Lopressor. A clinical evaluation of sustained release metoprolol durules in the treatment of angina pectoris. Comparison of the inotropic and chronotropic effects of metoprolol and propranolol.

Journal of Clinical Pharmacology Left ventricular hypertrophy regression in hypertensive patients treated with metoprolol. Age and responses to isometric exercise in hypertension: Hormonal and substrate responses during recovery from hypoglycaemia in man during beta1-selective and non-selective beta-adrenergic blockade.

European Journal of Clinical Investigation Oral beta-adrenergic blockade with metoprolol in chronic severe dilated cardiomyopathy. Journal of the American College of Cardiology 3: A pharmacokinetic and platelet function study of the combined administration of metoprolol and sulfinpyrazone to healthy volunteers. CNS-related side-effects with metoprolol and atenolol. European Journal of Clinical Pharmacology 28 Suppl.

Comparison of the duration of antihypertensive action of atenolol and metoprolol over a hour period. Current Medical Research and Opinion 9: Comparative study of hydrochlorothiazide and a fixed combination of metoprolol and hydrochlorothiazide in essential hypertension. Acta Medica Scandinavica Adrenergic mechanisms in control of plasma lipid concentrations.

British Medical Journal Antihypertensive efficacy of slow-release metoprolol and chlorthalidone as fixed combination: The influence of propranolol, metoprolol, and mepindole on mucocilary clearance in coronary heart disease patients without pulmonary disease. Acute effects of lignocaine, procainamide, metoprolol, digoxin and atropine on human myocardial refractoriness. Effects of acute and chronic beta-receptor blockade on ventricular repolarisation in man.

British Heart Journal Effects of treatment with nifedipine and metoprolol in essential hypertension. Antihypertensive effects at rest and during exercise of a calcium blocker, nifedipine, alone and in combination with metoprolol. Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: The effect of metoprolol and atenolol on plasma high density lipoprotein levels in man.

Clinical and Experimental Pharmacology and Physiology 7: British Journal of Clinical Pharmacology 13 Suppl. Deutsche Medizinische Wochenschrift Effects of anti-hypertensive therapy on serum lipoproteins treatment with metoprolol, propranolol and hydrochlorothiazide. Complaints of cold extremities among patients on antihypertensive treatment. Effect of metoprolol on cardiac and pulmonary function in chronic obstructive pulmonary disease.

Suppression of ventricular ectopy with intravenous metoprolol in patients with chronic obstructive pulmonary disease. Critical Care Medicine The effect of metoprolol on the glucose, insulin and glucagon response to glucose oral load in normal and diabetic subjects. Exercise training during chronic beta blockade in cardiovascular disease. Ambulatory blood pressure during once-daily randomised double-blind administration of atenolol, metoprolol, pindolol, and slow-release propranolol.

A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension. Journal of International Medical Research Effects of cardioselective and nonselective beta-adrenergic antagonists on pulmonary mechanisms. Relation of cardiovascular response to the hypotensive effect of metoprolol. American Heart Journal Beta-blocker therapy in severe heart failure: Excessive plasma dopamine increase at rest and during exercise after long-term beta-adrenoceptor blockade in hypertensive patients.

Journal of Hypertension 3: Comparison of two long-acting preparations of metoprolol with conventional metoprolol and atenolol in healthy men during chronic dosing. Multi-clinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension. American Journal of Medicine Study of the influence of nifedipine on the pharmacokinetics and pharmacodynamics of propranolol, metoprolol and atenolol.

British Journal of Clinical Pharmacology 17 Suppl. Metoprolol in the treatment and prophylaxis of paroxysmal reentrant supraventricular tachycardia. Journal of Cardiovascular Pharmacology 4: Investigation of drug absorption from the gastrointestinal tract of man.

Metoprolol in the colon. Comparative pharmacokinetic profiles of metoprolol and chlorthalidone administered alone or in combination to healthy volunteers. The treatment of high blood pressure in the elderly: Current Medical Research and Opinion 7: A fixed combination of metoprolol and chlorthalidone in hypertension. South African Medical Journal Comparative study of the ventilatory effects of three beta1-selective blocking agents in asthmatic patients.

Ventilatory and haemodynamic effects of terbutaline infusion during beta1-selective blockade with metoprolol and acebutolol in asthmatic patients. A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation. Thrombosis and Haemostasis Influence of beta-blocking drugs on glucose metabolism in patients with non-insulin dependent diabetes mellitus.

Influence of beta-blocking drugs on glucose metabolism in hypertensive, non-diabetic patients. Time course of blood pressure, pulse rate, plasma renin and metoprolol during treatment of hypertensive patients.

Influence of hyperthyroidism on the kinetics of methimazole, propranolol, metoprolol and atenolol. A Nordic multicentre dose-response study of metoprolol in angina pectoris patients. Beta-blockers in the prevention of myocardial infarction. Cardiac dysrhythmia associated with general anaesthesia for oral surgery.

Effects of penbutolol and metoprolol on blood pressure, plasma catecholamines and renin activity in hypertensive patients. European Heart Journal 4 Suppl.

Drug Treatment, 2nd ed. Metoprolol medication and coronary artery bypass grafting operation. Acta Anaesthesiologica Scandinavica Haemodynamic dose-response effects of i. Successful treatment of supraventricular tachycardia with metoprolol, a cardioselective beta-blocker. Effect of metoprolol on indirect signs of the size and severity of acute myocardial infarction. Effect of metoprolol on chest pain in acute myocardial infarction. Tolerability to treatment with metoprolol in acute myocardial infarction in relation to age.

Development of congestive heart failure after treatment with metoprolol in acute myocardial infarction. Relationship between infarct size and incidence of severe ventricular arrhythmias in a double-blind trial with metoprolol in acute myocardial infarction.

International Journal of Cardiology 6: The gastrointestinal absorption of drugs in man: Acute intervention with metoprolol in myocardial infarction. Acta Medica Scandinavica Suppl. Early intervention with a beta-blocking drug after acute myocardial infarction. Effect on mortality of metoprolol in acute myocardial infarction. The effect of impaired renal function on the plasma concentration and urinary excretion of metoprolol metabolites. The dose is adjusted to the nearest strength tablets.

Your doctor may increase the dose to 1. Larger than the mg dose in children and adolescents has not been studied. Z Metoprolol Sandoz tablets are not recommended for use in children less than 6 years of age.

The duration of treatment prescribed by your doctor. If you think that Metoprolol Sandoz Z caused by too strong or too weak effects, talk to your doctor or pharmacist. Elderly Older than 80 years of clinical studies, your gydyojas didinandamas doses have to be particularly careful if you are older than 80 years.

You have to drink a prolonged-release tablets once a day, preferably at breakfast. You can swallow the prolonged-release tablet whole or in part, but avoid them chew or crush. Metoprolol Sandoz Z always exactly as directed by your doctor.

If you take a large dose of Metoprolol Sandoz Z Immediately contact your doctor or emergency doctor, who will decide this case based on the severity of the symptoms of poisoning, what measures are appropriate.

Keep the medicine container with you to the doctor to find out what materials you have taken, and the introduction of appropriate measures. The first signs of overdose occurred after 20 minutes. Metoprolol Sandoz Z after ingestion and strong overdose effects can last for several days. Management of overdose The patient should be placed in a hospital and being treated in the intensive care conditions.

Even apparently healthy patients who have drug overdose a few, should be carefully monitored for signs of poisoning for at least 4 hours. In comparison to conventional metoprolol, the plasma metoprolol levels following administration of TOPROL-XL are characterized by lower peaks, longer time to peak and significantly lower peak to trough variation.

The peak plasma levels following once-daily administration of TOPROL-XL average one-fourth to one-half the peak plasma levels obtained following a corresponding dose of conventional metoprolol, administered once daily or in divided doses.

The bioavailability of metoprolol shows a dose-related, although not directly proportional, increase with dose and is not significantly affected by food following TOPROLXL administration. The pharmacokinetics of metoprolol were similar to those described previously in adults. Age, gender, race, and ideal body weight had no significant effects on metoprolol pharmacokinetics.

Clinical Studies In five controlled studies in normal healthy subjects, the same daily doses of TOPROL-XL and immediate-release metoprolol were compared in terms of the extent and duration of beta1 — blockade produced.

Both formulations were given in a dose range equivalent to mg of immediaterelease metoprolol per day. A sixth controlled study compared the beta1 -blocking effects of a 50 mg daily dose of the two formulations. In each study, beta1 -blockade was expressed as the percent change from baseline in exercise heart rate following standardized submaximal exercise tolerance tests at steady state. TOPROL-XL administered once a day, and immediate-release metoprolol administered once to four times a day, provided comparable total beta1 -blockade over 24 hours area under the beta1 -blockade versus time curve in the dose range mg.

For TOPROL-XL, the percent reduction in exercise heart rate was relatively stable throughout the entire dosage interval and the level of beta1 -blockade increased with increasing doses from 50 to mg daily. In contrast to TOPROL-XL, immediate-release metoprolol given at a dose of mg once a day produced a significantly larger peak effect on exercise tachycardia, but the effect was not evident at 24 hours.

A controlled cross-over study in heart failure patients compared the plasma concentrations and beta1 -blocking effects of 50 mg immediate-release metoprolol administered t.

Tratamentul cu metoprolol trebuie intrerupt cu ore inainte de data probabila a nasterii. Daca acest lucru nu este posibil, nou-nascutul trebuie tinut sub supraveghere timp de ore dupa nastere. Alaptarea Metoprololul se concentreaza in laptele matern. Desi riscul de reactii adverse asupra sugarului pare a fi redus dupa dozele terapeutice de medicament, sugarul trebuie tinut sub supraveghere pentru evidentierea semnelor rezultate din mecanismul de actiune al medicamentului.

Conducerea vehiculelor si folosirea utilajelor: In timpul tratamentului cu comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg pot sa apara ameteala si oboseala. Aceste efecte pot influenta negativ capacitatea de a conduce vehicule sau de a folosi utilaje si pot fi exacerbate de utilizarea concomitenta cu alcool etilic sau dupa inlocuirea medicamentului Informatii importante privind unele componente ale MetoSuccinat Sandoz 47,5 mg: Acest medicament contine lactoza, zahar, glucoza.

Daca medicul dumneavoastra v-a atentionat ca aveti intoleranta la unele categorii de glucide, va rugam sa-l intrebati inainte de a utiliza acest medicament. Va rugam sa spuneti medicului dumneavoastra sau farmacistului daca luati sau ati luat recent orice alte medicamente, inclusiv dintre cele eliberate fara prescriptie medicala. Interactiuni legate de mecanismul de actiune Daca utilizati medicamente cu actiune inhibitoare asupra unei parti a sistemului nervos vegetativ blocante ale ganglionilor simpatici in asociere cu alte beta-blocante de exemplu, picaturi oftalmice sau inhibitori de MAO anumite medicamente pentru tratarea depresiilor , starea clinica trebuie supravegheata foarte atent de catre medic.

Daca tratamentul cu clonidina trebuie intrerupt, in cazul administrarii clonidinei concomitent cu metoprolol, administrarea de comprimate filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg trebuie intrerupta cu cateva zile inaintea intreruperii administrarii clonidinei. Daca urmati un tratament comprimate filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg concomitent cu antagonisti ai canalelor de calciului de tipul verapamilului sau diltiazemului sau cu medicamente pentru tratamentul tulburarilor de ritm cardiac antiaritmice , trebuie sa fiti monitorizati de catre medic pentru evidentierea oricaror efecte negative asupra frecventei cardiace si asupra ritmului cardiac.

Blocantele canalelor de calciu de tipul verapamilului nu trebuie sa vi se administreze intravenos daca sunteti tratat concomitent cu beta-blocante de exemplu, comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg. Antiaritmicele din clasa I anumite medicamente pentru tratamentul tulburarilor de ritm cardiac si beta-blocantele de exemplu: Asocierea nu trebuie utilizata la pacientii cu tulburari de conducere a excitabilitatii cardiace sindrom de sinus bolnav si cu tulburari de conducere atrio-ventriculara de gradul I si II.

Interactiunea a fost descrisa in special pentru disopiramida. La pacientii aflati in tratament cu beta-blocante de exemplu, comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg , efectul de incetinire a pulsului se amplifica in cazul administrarii concomitente cu anestezice inhalatorii.

Comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg pot amplifica actiunea medicamentelor hipotensoare administrate concomitent. Daca se administreaza comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg concomitent cu noradrenalina, adrenalina acestea sunt substante produse si in mod natural in organism, mediatori chimici care actioneaza ca stimulanti asupra sistemului cardiovascular, crescand tensiunea arteriala sau cu alte medicamente care mimeaza actiunea simpaticului simpatomimetice , tensiunea arteriala poate creste semnificativ.

Utilizarea concomitenta de comprimate filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg si rezerpina, alfa-metildopa, clonidina, guanfacina si glicozizi digitalici poate determina scaderea semnificativa a pulsului si a conductibilitatii intracardiace.

Daca urmati tratament concomitent cu alte beta-blocante de exemplu, picaturi oftalmice care contin substanta activa timolol trebuie sa fiti supravegheat cu atentie. Comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg pot masca manifestarile determinate de un nivel scazut al glucozei in sange, in special acelerarea pulsului tahicardie , avand drept urmare neevidentierea unei eventuale hipoglicemii.

Beta-blocantele de exemplu, comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg pot inhiba eliberarea insulinei la pacientii cu diabet zaharat de tip 2. Este necesar controlul regulat al glicemiei, iar tratamentul de scadere a glicemiei insulina sau antidiabetice orale trebuie adaptat in mod corespunzator. Daca utilizati concomitent medicamente antiinflamatoare de exemplu, indometacin sau alti inhibitori ai sintezei prostaglandinei , actiunea de scadere a tensiunii arteriale determinata de beta-blocante se poate diminua.

Daca in anumite situatii vi se administreaza adrenalina, un beta-blocant cardiac selectiv cum sunt comprimatele filmate cu eliberare modificata de MetoSuccinat Sandoz 47,5 mg are un efect cert mai slab asupra controlului tensiunii arteriale decat un beta-blocant neselectiv.

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